The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling
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چکیده
منابع مشابه
Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3
Despite the importance of Ras oncogenes as a therapeutic target in human cancer, their 'undruggable' tertiary structures limit the effectiveness of anti-Ras drugs. Canonical Wnt signaling contributes to Ras activity by glycogen synthase kinase 3 (GSK-3)-dependent phosphorylation at the C-terminus and subsequent degradation. In the accompanying report, we show that the anti-helminthic niclosamid...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2009
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi9009677